Vitamin E + Multivitamin

Warning

Remember to consult a healthcare professional before taking Vitamin E + Multivitamin supplements.

What Is Vitamin E + Multivitamins (Ca, Mg, D3, Zn)?

Vitamin E is found naturally in some foods and is available as a dietary supplement. Vitamin E possesses antioxidant properties.

Good sources of Vitamin E include:

• Sunflower seeds

• Wheat germ oil

• Almonds

• Peanuts

• Spinach

• Broccoli

• Mango

• Tomato

Regimen	Details
What	Oral capsules
Dosage	Vitamin E: 400mg (RDA = 15mg; tolerable upper limit = 1000mg) Multivitamin: 1000mg Calcium carbonate (RDA = 1000mg) + 240mg Magnesium oxide (RDA = 340mg) + 500 IU Vitamin D3 (RDA = 600 IU) + 11mg Zinc sulphate (RDA = 8mg)
How to Use	Vitamin E: Take one capsule from 15 days before the period until the start of the period for 2 menstrual cycles Multivitamin: Take one capsule daily for 2 months

Note

Recommended Dietary Allowance (RDA): Average daily level of intake sufficient to meet the nutrient requirements of nearly all (97–98%) healthy individuals; often used to plan nutritionally adequate diets for individuals.¹

How Does Vitamin E Work?

With its antioxidant properties, vitamin E reduces phospholipid peroxidation and inhibits the release of arachidonic acid and its conversion to prostaglandins. Therefore, it can play a significant role in relieving the severity of dysmenorrhea.²

What Is the Efficacy of Vitamin E + Multivitamins for Period Cramps?

Methods: Studies were done to assess the efficacy of vitamin E in treating dysmenorrhea. Women with primary dysmenorrhea were randomly assigned to take either vitamin E, calcium (alone or combined with magnesium), or calcium with vitamin D, or a placebo. Vitamin E was given for a few days before and during menstruation, and the minerals from mid-cycle until the pain stopped. Pain levels, duration, and sometimes menstrual blood loss or painkiller use were recorded over several cycles to compare the effects of the supplements with placebo.^3,4,5

Results: All three studies found that the supplements helped reduce menstrual pain compared to placebo. Vitamin E significantly lowered both the severity and duration of pain, while calcium and magnesium together showed greater pain relief than calcium alone.

Conclusions: Overall, vitamin E and mineral supplements like calcium and magnesium can help lessen the pain of primary dysmenorrhea, making periods more manageable.

What Are the Side-Effects of Vitamin E?

• Short-term effects: Weakness, fatigue.

• Long-term effects: Bruising, excess bleeding.⁶

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Medically reviewed by

Dr Yash Bahuguna

Researched by

Dr Inara Isani

Written by

Dr Diksha Sheoraut

References

1. Office of Dietary Supplements, National Institutes of Health. Nutrient Recommendations and Databases. [Internet]. Bethesda (MD): National Institutes of Health; [cited 2025 May 20]. Available from: https://ods.od.nih.gov/HealthInformation/nutrientrecommendations.aspx

2. Sadeghi N, Paknezhad F, Rashidi Nooshabadi M, Kavianpour M, Jafari Rad S, Khadem Haghighian H. Vitamin E and fish oil, separately or in combination, on treatment of primary dysmenorrhea: a double-blind, randomized clinical trial. Gynecological Endocrinology. 2018 Sep 2;34(9):804-8.

3. Vilvapriya S, Vinodhini S. Vitamin E in the treatment of primary dysmenorrhoea. Int J Reprod Contracept Obstet Gynecol. 2018 Jun;7(6):2257–61. doi:10.18203/2320-1770.ijrcog20182331.

4. Charandabi SM, Mirghafourvand M, Nezamivand-Chegini S, Javadzadeh Y. Calcium with and without magnesium for primary dysmenorrhea: a double-blind randomized placebo controlled trial. Int J Women’s Health & Repro Sci. 2017 Oct 1;5(4):332-8.

5. Zarei S, Mohammad-Alizadeh-Charandabi S, Mirghafourvand M, Javadzadeh Y, Effati-Daryani F. Effects of calcium-vitamin D and calcium-alone on pain intensity and menstrual blood loss in women with primary dysmenorrhea: a randomized controlled trial. Pain medicine. 2017 Jan 1;18(1):3-13.

6. Owen KN, Dewald O. Vitamin E Toxicity StatPearls 2021 [Internet].